usa flag
NYSEMKT:ATNM
SPONSORED

Could This Pivotal Phase 3 Trial Cure Active, Relapsed, or Refractory Acute Myeloid Leukemia?(1)

Get a Leg Up and Learn About ​​Actinium Pharmaceuticals (NYSE:ATNM)- Potentially the Next Explosive Biotech Breakout

October 1, 2021
Actinium Announces Two Abstracts Highlighting Combinations of CD47 Targeting Immunotherapy with Targeted Radiotherapies in Solid Tumors and Blood Cancers Accepted for Presentation at Society for Immunotherapy for Cancer (SITC) Conference

Biotech stocks can start as little known afterthoughts and turn into explosive disruptors on the cusp of revolutionizing medicine in months, weeks, or even days.

For example, did you even know who Moderna was 18 months ago?

On March 20, 2020, Moderna was nothing but a little-known biotech innovator developing an experimental vaccine trading at $30.05. By the close on September 21, 2017, the stock was trading at $434.04. For those not counting, that’s a rapid 1,300%+ breakout.(2)

Amidst the continued carnage of the worldwide health situation, many other biotech stocks have also seen their shares skyrocket year-to-date in 2021:(3)

  • KemPharm, Inc. 1,125.00%
  • Novan, Inc. 956.58%
  • Onconova Therapeutics, Inc. 939.07%
  • PDS Biotechnology Corporation 614.95%
  • Acasti Pharma, Inc. 580.00%

Get this, though.

Have any of those stocks caught potential support? Did a well-respected analyst give them a price target showing 450+% of room to run from its September 21, 2021 close?(4)

Are any of those stocks in the midst of a Phase 3 trial that could potentially cure one of the most debilitating forms of cancer we know- relapsed or recurrent, acute myelogenous leukemia (AML)?

Meet Actinium Pharmaceuticals (NYSE: ATNM). This clinical-stage biopharmaceutical company could completely revolutionize medicine. All by developing targeted radiotherapies that deliver cancer-killing radiation with cellular-level precision.

Based on recent history, when biotech companies find a solution, the results can be life-changing. Keep a very close eye on this company as its Iomab-B treatment progresses through Phase III SIERRA trials.

That’s why we put together this comprehensive research report on Actinium Pharmaceuticals (NYSE: ATNM), which we’re thrilled to send your way. We’re about to reveal the top 5 reasons to strongly consider this company ASAP and why it could be on the cusp of a historic breakout.

We have a long track record of finding diamonds in the rough. Actinium Pharmaceuticals (NYSE: ATNM) could be our latest and greatest find.

Reason #1: There is Demand For a Leukemia Cure…and the Market Looks Lucrative

The leukemia therapeutics market could reach $17.1 billion by 2024 from $12.3 billion in 2019, at a CAGR of 6.8%.(5)

Do you know what’s driving this market? A rising prevalence of acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). The increasing number of approvals of novel & innovative drugs and immunotherapies don’t hurt either.(5)

Say hello to a wide-open opportunity for Actinium Pharmaceuticals (NYSE: ATNM).

AML, or acute myeloid leukemia, is precisely an unmet need- especially for younger people. According to Eunice Wang, MD, Chief of the Leukemia Service at Roswell Park Comprehensive Cancer Center, as quoted by Check Rare, (Source 6) it is rarely diagnosed in patients under the age of 45.

At the moment, the five-year survival rate for those 20 and older is also putrid 26%.(7)

Some must also contend with relapsed, or recurrent, acute myelogenous leukemia (AML), which means leukemia came back after treatment and after reaching remission. Refractory AML means leukemia did not respond to treatment. Complete remission can’t be achieved because chemotherapy wasn’t able to kill off enough leukemia cells.(8)

Reason #2: Actinium’s Iomab-B Could Be Nearing a Treatment With SIERRA trials.

When you want to find a biotech play, you have to think this way- “don’t talk about it, be about it.”

Well, Actinium isn’t just talking. It’s backing it up.

On September 15, Actinium announced enrollment for its pivotal Phase III SIERRA trial of Iomab-B was complete.(1)

SIERRA is a 150-patient, multicenter, randomized trial studying Iomab-B, an antibody-radiation conjugate comprising an anti-CD45 antibody and radioactive iodine-131 (I-131), compared with salvage chemotherapy inactive, relapsed, or refractory acute myeloid leukemia (AML).

Enrollment completion is an appropriate conclusion to the trial, which has been ongoing for five years. This latest announcement is entirely in line with previous management guidance.

“Iomab-B was developed to address the significant unmet need of patients who could benefit and possibly be cured of their blood cancer with a bone marrow transplant but could not receive a transplant because non-targeted conditioning regimens could not produce a remission or are too toxic in this patient population. We are confident that Iomab-B will squarely address this unmet need given its targeted nature and ability to deliver high amounts of radiation directly to the bone marrow resulting in myeloablation while sparing healthy organs,” said Dr. Avinash Desai, Actinium Pharmaceuticals’ Executive VP, Clinical Development.(9)

We should know more about its success by the fourth quarter of 2021.

That’s when, according to the company, “Actinium expects to present data updates from the SIERRA trial in the fourth quarter of 2021 and to announce topline data for the primary endpoint of six-month durable Complete Remission (dCR) in mid-2022. These data are expected to support registration of a Biologics License Application (BLA) for Iomab-B.”(9)

In short, if things continue progressing the way they are, Actinium Pharmaceuticals (NYSE:ATNM) could be a game-changer.

Reason #3: The SIERRA Trial is the ONLY Randomized Phase 3 Trial to Offer Bone Marrow Transplants (BMT)(9)

The company’s SIERRA trial for Iomab-B is a 150-patient, randomized 1:1 pivotal Phase 3 trial studying Iomab-B compared to physician’s choice of salvage chemotherapy in patients age 55 and above with active, relapsed, or refractory AML or acute myeloid leukemia.(9)

Cool right?

Here’s the kicker, though. This trial is believed to be the ONLY randomized Phase 3 trial to offer BMT, the only potentially curative treatment option, to this patient population.(9)

Plus, Iomab-B is radiotherapy that targets cells expressing CD45. This protein is found only on blood cancer cells and immune cells, including bone marrow stem cells, with the radioisotope iodine-131. It is intended to be a targeted conditioning agent to enable potentially curative BMTs.(9)

This could completely revolutionize the medical community…especially when you consider how impressive trial data already looks: (12)

  • 100% engraftment consistent throughout interim analyses at 25%, 50%, and 75% of patient enrollment despite heavy leukemia burden before Iomab-B treatment.
  • Personalized Iomab-B therapy enables targeted delivery of radiation to the bone marrow enabling myeloablation in a well-tolerated manner.
  • Iomab-B delivers high amounts of targeted radiation to the bone marrow with minimal impact on other organs resulting in lower rates and severity of adverse events.

Wake up and smell the Iomab-B. If all goes according to plan Actinium Pharmaceuticals (NYSE:ATNM) could completely transform cancer treatment.

Reason #4: The Strengthening Its Patent Portfolio with International IP

Why limit yourself to one domestic market if you have such a potentially strong treatment candidate that could change the entire world?

Actinium recently announced that its intellectual property portfolio around Iomab-B, has been further strengthened internationally.(13)

  • In the EU, Actinium has been issued a patent covering the composition and methods administration of Iomab-B, an Antibody Radiation Conjugate (ARC) comprised of apamistamab, a CD45 targeting antibody, and the radioisotope iodine-131. The issued patent in the EU is expected to have a useful life through 2036.
  • In addition, Actinium has been granted a patent covering the same composition and methods of administration claims in Japan.

According to Dr. Dale Ludwig, Actinium’s Chief Scientific Officer:

“We are excited to expand our already robust patent portfolio with these key patents in the EU and Japan. As the only CD45 ARC for targeting conditioning in clinical development, these international patents, together with our U.S. patents lay the foundation for aggressive development of Iomab-B for BMT conditioning and Iomab-ACT for conditioning prior to cell and gene therapies. Iomab-B is well characterized and supported by extensive clinical data across multiple clinical trials and indications.”

“Our ARC approach has significant advantages over other approaches such as monoclonal antibodies or antibody drug conjugates that require payload internalization, making them impractical for targeting CD45. We look forward to continuing to build our leadership position in targeted conditioning led by Iomab-B and remaining at the forefront of innovation in targeted radiotherapy.”

Reason #5: Analysts Are Going Crazy Over ATNM’s Potential Upside 

While the ATNM stock did pull back in recent months, it may have caught strong double bottom support around $6.85.

With new, potentially exciting developments within the company, the stock may have the potential to retest prior highs around $20 a share and start an explosive breakout. In just ONE WEEK, for instance, the stock saw a low of $5.70 on September 14, 2021, and popped an astounding 42.11% to its September 21, 2021 closing price of $8.10. (15)

Many analysts are also not just going long on this stock. They’re going all in.

William Blair, for one, gives the stock an “Outperform” rating with a risk-adjusted fair value of $11.12 per share value.(10)

Blair also stated that the “company finished the second quarter with a cash level of $81.9 million, which according to our estimates will likely sustain company operations into the first half of 2023, potentially beyond the Phase III SIERRA trial top-line readout.”(10)

Most importantly, “Pending positive results from the Phase III SIERRA study and successful regulatory interactions with the FDA, [​​Iomab-B] is poised to disrupt the $600 million preconditioning market in the United States and Europe.”(10)

Other analysts are even more bullish on the stock.

After ATNM announced full enrollment for its Phase III SIERRA Trial, Jones Trading immediately gave the company a $40 price target.(16) That would give it potentially 393.83% of room to run from its $8.10 closing price on September 21, 2021. Moreover, Jones Trading forecasted Actinium to see approximately $500 million in peak sales by 2032.(16)

But what if I told you that this isn’t even the most bullish analyst call?! H.C. Wainwright gave the stock a $45 price target!(4) That would give it potentially 455.56% of room to run!

455.56%!

Based on this rating, H.C. Wainwright says that “the common stock of the company is expected to outperform a passive index composed of all the common stock of companies within the same sector.”(4)

To Sum It Up…

Biotech stocks are either hit or miss. But when they hit, the potential upside can be massive. Actinium Pharmaceuticals (NYSE: ATNM) could be our latest and most significant find in the biotech sector. It has a potentially revolutionary treatment rapidly progressing and the possibility to change the face of medicine as we know it.

Yet, outside of its trial results already looking promising, the stock may be on the cusp of a historic breakout.

And analysts see it.

If you don’t watch this one closely, you may regret it.

 

Source 1: https://ir.actiniumpharma.com/press-releases/detail/401
Source 2: https://finance.yahoo.com/quote/MRNA/history?p=MRNA
Source 3: https://fknol.com/list/best-performing/biotech-stocks.php
Source 4: Client Provided Analyst Material HC Wainwright
Source 5: https://www.marketsandmarkets.com/Market-Reports/chronic-lymphocytic-leukemia-223.html
Source 6: https://checkrare.com/targeted-therapy-for-acute-myeloid-leukemia/
Source 7: https://www.cancer.net/cancer-types/leukemia-acute-myeloid-aml/statistics
Source 8: https://cancer.ca/en/cancer-information/cancer-types/acute-myelogenous-leukemia-aml/treatment/relapsed-or-refractory
Source 9: https://www.prnewswire.com/news-releases/actinium-completes-enrollment-in-the-pivotal-phase-3-sierra-trial-of-iomab-b-301377219.html
Source 10: Client Provided Analyst Material William Blair
Source 11: https://d1io3yog0oux5.cloudfront.net/_7a9aad056eac4863c502660ef790af6d/actiniumpharma/db/206/944/pdf/Actinium_InvestorPresentation_September+2021.pdf
Source 12: https://ir.actiniumpharma.com/press-releases/detail/398/pivotal-phase-3-sierra-trial-data-showing-100-bone-marrow
Source 13: https://www.prnewswire.com/news-releases/actinium-further-strengthens-patent-portfolio-with-international-ip-covering-the-composition-and-methods-of-administration-of-iomab-b-antibody-radiation-conjugate-in-the-eu-and-japan-301314557.html
Source 14: https://stockcharts.com/h-sc/ui?s=atnm
Source 15: https://stockcharts.com/h-sc/ui
Source 16: Client Provided Analyst Material Jones Trading

Legal Disclaimer


This website / media webpage is owned, operated and edited by TD Media LLC. Any wording found on this website / media webpage or disclaimer referencing to “I” or “we” or “our” or “TD Media” refers to TD Media LLC. This website / media webpage is a paid advertisement, not a recommendation nor an offer to buy or sell securities. Our business model is to be financially compensated to market and promote small public companies. By reading our website / media webpage you agree to the terms of our disclaimer, which are subject to change at any time. We are not registered or licensed in any jurisdiction whatsoever to provide investing advice or anything of an advisory or consultancy nature and are therefore are unqualified to give investment recommendations. Always do your own research and consult with a licensed investment professional before investing. This communication is never to be used as the basis for making investment decisions and is for entertainment purposes only. At most, this communication should serve only as a starting point to do your own research and consult with a licensed professional regarding the companies profiled and discussed. Conduct your own research. Companies with low price per share are speculative and carry a high degree of risk, so only invest what you can afford to lose. By using our service you agree not to hold our site, its editor’s, owners, or staff liable for any damages, financial or otherwise, that may occur due to any action you may take based on the information contained within our website / media webpage.We do not advise any reader take any specific action. Losses can be larger than expected if the company experiences any problems with liquidity or wide spreads. Our website / media webpage are for entertainment purposes only. Never invest purely based on our alerts. Gains mentioned in our website / media webpage may be based on end-of-day or intraday data. This publication and their owners and affiliates may hold positions in the securities mentioned in our alerts, which we may sell at any time without notice to our subscribers, which may have a negative impact on share prices. If we own any shares we will list the information relevant to the stock and number of shares here. TD Media business model is to receive financial compensation to promote public companies. To conduct investor relations advertising, marketing and publicly disseminate information not limited to our Websites, Email, SMS, Push Notifications, Influencers, Social Media Postings, Ticker Tags, Press Releases, Online Interviews, Podcasts, Videos, Audio Ads, Banner Ads, Native Ads, Responsive Ads. This compensation is a major conflict of interest in our ability to be unbiased regarding. Therefore, this communication should be viewed as a commercial advertisement only. We have not investigated the background of the hiring third party or parties. The third party, profiled company, or their affiliates likely wish to liquidate shares of the profiled company at or near the time you receive this communication, which has the potential to hurt share prices. Any non-compensated alerts are purely for the purpose of expanding our database for the benefit of our future financially compensated investor relations efforts. Frequently companies profiled in our alerts may experience a large increase in volume and share price during the course of investor relations marketing, which may end as soon as the investor relations marketing ceases. Our emails may contain forward-looking statements, which are not guaranteed to materialize due to a variety of factors We do not guarantee the timeliness, accuracy, or completeness of the information on our website / media webpage. The information in our website / media webpage is believed to be accurate and correct, but has not been independently verified and is not guaranteed to be correct. The information is collected from public sources, such as the profiled company’s website and press releases, but is not researched or verified in any way whatsoever to ensure the publicly available information is correct. Furthermore, TD Media often employs independent contractor writers who may make errors when researching information and preparing these communications regarding profiled companies. Independent writers’ works are double-checked and verified before publication, but it is certainly possible for errors or omissions to take place during editing of independent contractor writer’s communications regarding the profiled company(s). You should assume all information in all of our communications is incorrect until you personally verify the information, and again are encouraged to never invest based on the information contained in our written communications. The information in our disclaimers is subject to change at any time without notice.

INFLUENCER COMPENSATION

Pursuant to an agreement between TD Media LLC and Influencer, TD Media LLC has hired Influencer for a period beginning on 11/23/2020 and ending on 11/23/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have paid this Influencer nine hundred dollars USD.

Pursuant to an agreement between TD Media LLC and Influencer, TD Media LLC has hired Influencer for a period beginning on 11/23/2020 and ending on 11/23/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have paid this Influencer one thousand one hundred twenty five dollars USD.

Pursuant to an agreement between TD Media LLC and Influencer, TD Media LLC has hired Influencer for a period beginning on 11/25/2020 and ending on 11/25/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have paid this Influencer one thousand eight hundred fifty dollars USD.

Pursuant to an agreement between TD Media LLC and Influencer, TD Media LLC has hired Influencer for a period beginning on 12/07/2020 and ending on 12/07/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have paid this Influencer six hundred dollars USD.

Pursuant to an agreement between TD Media LLC and Influencer, TD Media LLC has hired Influencer for a period beginning on 12/08/2020 and ending on 12/08/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have paid this Influencer three hundred ten dollars USD.

COMPENSATION

Pursuant to an agreement between TD Media LLC and Venado Media LLC, TD Media LLC has been hired for a period beginning on 11/21/2020 and ending on 11/22/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid ten thousand dollars USD via bank wire transfer.

Pursuant to an agreement between TD Media LLC and Venado Media LLC, TD Media LLC has been hired for a period beginning on 11/21/2020 and ending on 11/22/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid ten thousand dollars USD via bank wire transfer. Pursuant to an agreement between TD Media LLC and Legends Media LLC, TD Media LLC has been hired for a period beginning on 11/23/2020 and ending on 12/04/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid an additional forty five thousand dollars USD via bank wire transfer. We own zero shares of (ATNM:US). To date we have been paid fifty five thousand dollars USD via bank wire transfer. To disseminate information about (ATNM:US) via digital communications.

Pursuant to an agreement between TD Media LLC and Venado Media LLC, TD Media LLC has been hired for a period beginning on 11/21/2020 and ending on 11/22/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid ten thousand dollars USD via bank wire transfer. Pursuant to an agreement between TD Media LLC and Legends Media LLC, TD Media LLC has been hired for a period beginning on 12/07/2020 and ending on 12/11/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have not been paid. We own zero shares of (ATNM:US). To date we have been paid fifty five thousand dollars USD via bank wire transfer. To disseminate information about (ATNM:US) via digital communications.

Pursuant to an agreement between TD Media LLC and Venado Media LLC, TD Media LLC has been hired for a period beginning on 11/21/2020 and ending on 11/22/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid ten thousand dollars USD via bank wire transfer. Pursuant to an agreement between TD Media LLC and Legends Media LLC, TD Media LLC has been hired for a period beginning on 03/22/2021 and ending on 05/07/2021 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid an additional forty thousand dollars USD via bank wire transfer. We own zero shares of (ATNM:US). To date we have been paid ninety five thousand dollars USD via bank wire transfer. To disseminate information about (ATNM:US) via digital communications.

Pursuant to an agreement between TD Media LLC and Venado Media LLC, TD Media LLC has been hired for a period beginning on 11/21/2020 and ending on 11/22/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid ten thousand dollars USD via bank wire transfer. Pursuant to an agreement between TD Media LLC and Legends Media LLC, TD Media LLC has been hired for a period beginning on 06/08/2021 and ending on 09/14/2021 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid an additional forty thousand dollars USD via bank wire transfer. We own zero shares of (ATNM:US). To date we have been paid one hundred thirty five thousand dollars USD via bank wire transfer. To disseminate information about (ATNM:US) via digital communications.

Pursuant to an agreement between TD Media LLC and Venado Media LLC, TD Media LLC has been hired for a period beginning on 11/21/2020 and ending on 11/22/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid ten thousand dollars USD via bank wire transfer. Pursuant to an agreement between TD Media LLC and Legends Media LLC, TD Media LLC has been hired for a period beginning on 09/15/2021 and ending on 09/17/2021 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid an additional fifteen thousand dollars USD via bank wire transfer. We own zero shares of (ATNM:US). To date we have been paid one hundred fifty thousand dollars USD via bank wire transfer. To disseminate information about (ATNM:US) via digital communications.

Pursuant to an agreement between TD Media LLC and Venado Media LLC, TD Media LLC has been hired for a period beginning on 11/21/2020 and ending on 11/22/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid ten thousand dollars USD via bank wire transfer. Pursuant to an agreement between TD Media LLC and Legends Media LLC, TD Media LLC has been hired for a period beginning on 09/20/2021 and ending on 09/26/2021 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid an additional fifty five thousand dollars USD via bank wire transfer. We own zero shares of (ATNM:US). To date we have been paid two hundred five thousand dollars USD via bank wire transfer. To disseminate information about (ATNM:US) via digital communications.

Pursuant to an agreement between TD Media LLC and Venado Media LLC, TD Media LLC has been hired for a period beginning on 11/21/2020 and ending on 11/22/2020 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid ten thousand dollars USD via bank wire transfer. Pursuant to an agreement between TD Media LLC and Legends Media LLC, TD Media LLC has been hired for a period beginning on 09/27/2021 and ending on 10/01/2021 to publicly disseminate information about (ATNM:US) via digital communications. We have been paid an additional forty thousand dollars USD via bank wire transfer. We own zero shares of (ATNM:US). To date we have been paid two hundred forty five thousand dollars USD via bank wire transfer. To disseminate information about (ATNM:US) via digital communications.

Company Contact

275 Madison Avenue 7th Floor
New York, NY 10016
www.actiniumpharmaceuticals.com
(646) 677-3870
[email protected]

Company Description

Actinium Pharmaceuticals Inc is a biopharmaceutical company engaged in the development of innovative-targeted therapies for patients with cancers lacking effective treatment options. The company’s proprietary technology platform utilizes monoclonal antibodies to deliver radioisotopes directly to cells of interest in order to kill those cells safely and effectively. Its most advanced products are Iomab-B, an antibody-drug construct containing iodine 131 (I-131), used for hematopoietic stem cells transplantation in various indications and Actimab-A, an antibody-drug construct containing actinium 225 (Ac-225), currently in human clinical trials for acute myeloid leukemia.